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ITPKA Antibody (C-term)

ITPKA Antibody (C-term)

ArtNr	ABC-AP8166b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Inositol 1, ITPKA, Inositol-trisphosphate 3-kinase A, 5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A
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Primary Accession	P23677
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of the inositol 1, 4, 5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
Bio References	Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004). Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002). Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001). Communi, D., et al., EMBO J. 16(8):1943-1952 (1997). Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).
Clonality	Polyclonal
Clone/Animal Names	RB5359
Gene ID	3706
Gene Name	ITPKA
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Western blot analysis of hITPKA-E360 (Cat.# AP8166b) in K562 cell line and mouse lung tissue lysates (35ug/lane). ITPKA (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	All lanes : Anti-ITPKA Antibody (C-term) at 1:1000 dilution Lane 1: human brain lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 51 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Other Accession	NP_002211
Isotype	Rabbit Ig
Calculated MW	51009
Antigen Region	345-375
Antigen Source	HUMAN
Target/Specificity	This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human ITPKA.
NCBI Accession	NP_002211.1

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Menge: 400 ul

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