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DUSP4 Antibody (C-term)

DUSP4 Antibody (C-term)

ArtNr	ABC-AP8447B
Hersteller	Abcepta
Menge	400 ul
Kategorie	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Chen, P., et al., J. Biol. Chem. 276(31):29440-29449 (2001). Smith, A., et al., Genomics 42(3):524-527 (1997). Chu, Y., et al., J. Biol. Chem. 271(11):6497-6501 (1996). King, A.G., et al., Oncogene 11(12):2553-2563 (1995). Guan, K.L., et al., J. Biol. Chem. 270(13):7197-7203 (1995).
NCBI	NP_001385.1,NP_476499.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,Mitogen-activated protein kinase phosphatase 2,MAP kinase phosphatase 2,MKP-2,DUSP4,MKP2,VH2
Similar products	DUSP4, MKP2, VH2, Dual specificity protein phosphatase 4, Dual specificity protein phosphatase hVH2, Mitogen-activated protein kinase phosphatase 2, MKP-2, MAP kinase phosphatase 2
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Manufacturer - Category	Primary Antibodies; Cell Biology; Signal Transduction
Manufacturer - Targets	This DUSP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human DUSP4.
Bio Background	DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB05733
Gene Name	DUSP4
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Calculated Molecular Weight	42953
Antigen Source	HUMAN
Antigen Region	331-361
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 WB: 1:1000 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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