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DUSP10 Antibody (N-term)

DUSP10 Antibody (N-term)

ArtNr	ABC-AP8453a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Tanoue, T., et al., J. Biol. Chem. 274(28):19949-19956 (1999). Theodosiou, A., et al., Oncogene 18(50):6981-6988 (1999). Martell, K.J., et al., Mol. Cells 8(1):2-11 (1998). Masuda, K., et al., Cytogenet. Cell Genet. 90 (1-2), 71-74 (2000) (): ().
NCBI	NP_009138.1,NP_653329.1,NP_653330.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Dual specificity protein phosphatase 10,Mitogen-activated protein kinase phosphatase 5,MAP kinase phosphatase 5,MKP-5,DUSP10,MKP5
Similar products	DUSP10, MKP5, Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MKP-5, MAP kinase phosphatase 5
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Manufacturer - Category	Primary Antibodies; Signal Transduction; Catalog Updated
Manufacturer - Targets	This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP10.
Bio Background	Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB5879
Gene Name	DUSP10
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Predicted Reactivity	B
Calculated Molecular Weight	52642
Antigen Source	HUMAN
Antigen Region	1-30
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 WB: 1:1000 IHC-P: 1:50~100 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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Lieferung vsl. bis 04.12.2025