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PPP6C Antibody (N-term)

PPP6C Antibody (N-term)

ArtNr	ABC-AP8477a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PP6C, PPP6C, N-terminally processed, PPP6, Serine/threonine-protein phosphatase 6 catalytic subunit
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Primary Accession	O00743
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	PPP6C belongs to the PPP phosphatase family, PP-V subfamily. Reversible phosphorylation of proteins on serine and threonine residues is an important biochemical event that regulates a broad variety of intracellular processes. The phosphorylation state is determined by the well-controlled balance of activities of serine/threonine-specific protein kinases and protein phosphatases, including PPP6C. Expression levels are highest in testis, heart, and skeletal muscle and lowest in placenta, lung, and kidney. PPP6C can complement mutations in the S. cerevisiae Sit4 and S. pombe ppe1 genes, indicating that PPP6C is the functional homolog of yeast Sit4p and ppe1. Since Sit4p is required for the G1 to S transition of the cell cycle and ppe1 is involved in cell shape control and mitotic division, it has been suggested that PPP6C functions in cell cycle regulation.
Bio References	Yang, J., et al., EMBO J. 24(1):1-10 (2005). Zhou, G., et al., J. Biol. Chem. 279(45):46595-46605 (2004). Huang, S., et al., J. Biol. Chem. 279(35):36490-36496 (2004). Swingle, M.R., et al., J. Biol. Chem. 279(32):33992-33999 (2004). Wechsler, T., et al., Proc. Natl. Acad. Sci. U.S.A. 101(5):1247-1252 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB5866
Gene ID	5537
Gene Name	PPP6C
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-PPP6C Pab (Cat. #AP8477a) is used in Western blot to detect PPP6C in Thymus cell lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	NP_002712.1
Isotype	Rabbit Ig
Calculated MW	35144
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPP6C.
NCBI Accession	NP_001116827.1; NP_001116841.1; NP_002712.1

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Menge: 400 ul

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