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LDLR Antibody (Center)

LDLR Antibody (Center)

ArtNr	ABC-AP8960C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	LDLR, LDL receptor, Low-density lipoprotein receptor
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Primary Accession	P01130
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.
Bio References	Hobbs, H.H., et.al., Hum. Mutat. 1 (6), 445-466 (1992) Brown, M.S. et.al., Proc. Natl. Acad. Sci. U.S.A. 76 (7), 3330-3337 (1979)
Clonality	Polyclonal
Clone/Animal Names	RB22886
Gene ID	3949
Gene Name	LDLR
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Western blot analysis of LDLR Antibody (Center) (Cat. #AP8960c) in mouse lung tissue lysates (35ug/lane). LDLR (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	LDLR Antibody (Center) (Cat.#AP8960c) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Other Accession	P35952; P20063; Q28832; P35951; P35950; Q99088; Q99087; P01131
Predicted	X, B, Ha, Pig, Rb, Rat
Isotype	Rabbit Ig
Calculated MW	95376
Antigen Region	391-419
Antigen Source	HUMAN
Target/Specificity	This LDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids of human LDLR.
NCBI Accession	NP_000518.1; NP_001182727.1; NP_001182728.1; NP_001182729.1; NP_001182732.1

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ABC-AP8960C-datasheet.pdf

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Menge: 400 ul

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