Artemin, human recombinant

Artemin is a ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (www.uniprot.org; Baloh et al. 1998, Neuron; Rosenblad et al. 2000, Eur. J. Biochem)

10 mM Na-citrate; 150 mM NaCl pH 4.5

Less than 1 EU/mg of protein as determined by LAL method

Purified from serum-free CHO growth media by ion-exchange chromatography and gel-filtration. Protein is sterile-filtered through 0.22 um filter

Q5T4W7