Ionomycin

ArtNr	HY-13434-50mg
Hersteller	MedChem Express
CAS-Nr.	56092-81-0
Menge	50 mg (14.1 mM x 5 mL in Ethanol)
Kategorie	Cell Biology Cell Status Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.27
Citations	[1]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.\|[2]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9.\|[3]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.\|[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18.\|[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358. ACS Infect Dis. 2023 Apr 14;9(4):979-992. Acta Pharm Sin B. 2024 Oct;14(10):4360-4377. Acta Pharmacol Sin. 2023 Apr;44(4):811-821. Adv Funct Mater. 2025 May 22. Adv Sci (Weinh). 2023 Mar;10(7):e2203869. Adv Sci (Weinh). 2024 Jul;11(26):e2400297. Adv Sci (Weinh). 2024 May;11(19):e2306378. Adv Sci (Weinh). 2025 Jun 19:e00225. Adv Sci (Weinh). 2025 Sep 15:e10102. Aging (Albany NY). 2021 Mar 24;13(7):10312-10325. Aging. 2019 Aug 19;11(16):6490-6502. Aging. 2021 Jun 2;13(11):15638-15658. Arch Oral Biol. 2024 Jul 3:166:106043. Biochem Pharmacol. 2024 Jan:219:115957. Biochem Pharmacol. 2025 Dec;242(Pt 3):117406. Biomed Pharmacother. 2022 Mar:147:112644. Biomed Pharmacother. 2024 May:174:116551. BMC Med. 2023 Dec 20;21(1):507. BMC Med. 2025 Mar 31;23(1):189. Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12. Cancer Commun (Lond). 2022 Jan;42(1):17-36. Cancer Immunol Res. 2025 Jul 2;13(7):1037-1052. Cancer Res. 2023 Mar 15;83(6):906-921. Cell Calcium. 2022 Jun;104:102571. Cell Death Differ. 2025 Apr 16. Cell Death Dis. 2021 Apr 1;12(4):336. Cell Death Dis. 2025 Apr 15;16(1):301. Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X. Cell Mol Immunol. 2022 Apr;19(4):540-553. Cell Mol Life Sci. 2025 May 28;82(1):218. Cell Rep. 2021 Jul 20;36(3):109404. Cell Rep. 2024 Mar 23;43(4):114003. Cell Rep. 2025 Jun 12;44(6):115857. Cell Rep. 2025 Jun 13;44(6):115851. Cell Rep. 2025 Sep 1;44(9):116139. Cell Res. 2025 Feb;35(2):97-116. Cell Stem Cell. 2025 May 1;32(5):778-794.e10. Cell. 2025 Dec 11;188(25):7291-7308.e23. Cytotechnology. 2024 Apr 24:1-8. EBioMedicine. 2024 Aug 6:106:105269. Ecotoxicol Environ Saf. 2024 Jan 15:270:115831. EMBO Rep. 2025 Nov 17. Eur J Med Res. 2025 May 12;30(1):378. Eur J Pharmacol. 2022 Feb 5:916:174623. Evid Based Complement Alternat Med. 2021 Jan 6:2021:8868527. Fish Shellfish Immunol. 2024 May:148:109515. Fish Shellfish Immunol. 2024 Nov:154:109975. Front Immunol. 2022 Aug 5:13:918241. Gut Microbes. 2024 Jan-Dec;16(1):2410474. Hum Reprod. 2024 Apr 3;39(4):658-673. Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865. Int Immunopharmacol. 2024 Sep 16;142(Pt B):113170. Int Immunopharmacol. 2025 May 20:159:114897. Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115803. Int J Biol Macromol. 2023 Jul 31:244:125373. Int J Mol Sci. 2023 Aug 8;24(16):12557. Int J Mol Sci. 2025 Jun 1;26(11):5332. Int J Mol Sci. 2025 May 20;26(10):4913. iScience. 2025 May 13;28(7):112658. J Cell Mol Med. 2024 Aug;28(15):e18589. J Cell Mol Med. 2025 Feb;29(3):e70403. J Cell Mol Med. 2025 Oct;29(20):e70915. J Clin Invest. 2025 Aug 1;135(15):e191119. J Ethnopharmacol. 2023 Mar 1:303:116031. J Immunol. 2021 Mar 1;206(5):963-977. J Immunother Cancer. 2024 Dec 9;12(12):e009910. J Immunother Cancer. 2025 Jul 31;13(7):e012029. J Nanobiotechnology. 2024 Sep 12;22(1):556. J Neuroimmunol. 2020 Aug 15;345:577286. J Periodontol. 2025 Apr;96(4):355-368. J Transl Med. 2024 Dec 20;22(1):1125. J Transl Med. 2025 Nov 14;23(1):1289. Microorganisms. 2023 Feb 27;11(3):604. Mol Cell. 2022 Jul 7;82(13):2401-2414.e9. Mol Med. 2024 Jul 30;30(1):110. Nat Cancer. 2025 May;6(5):768-785. Nat Commun. 2023 Feb 23;14(1):1020. Nat Commun. 2025 Mar 19;16(1):2728. Nat Commun. 2025 Nov 24;16(1):10384. Oncol Rep. 2024 Feb;51(2):29. Phytomedicine. 2025 Jun 20:145:157017. PLoS Pathog. 2025 Feb 4;21(2):e1012912. PLoS Pathog. 2025 Nov 14;21(11):e1013686. Preprints. 2023 Mar 6. Preprints. 2025 Feb 12. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119. Protein Cell. 2022 Apr;13(4):281-301. Redox Biol. 2023 Dec:68:102959. Reprod Fert Develop. 33(2) 108-108. Research Square Preprint. 2023 Aug 11. Research Square Print. 2022 Jun. Sci Signal. 2023 Feb 28;16(774):eadd0645. Sci Total Environ. 2021 Jul 20:779:146523. Sci Transl Med. 2020 Nov 25;12(571):eaaz6667. SSRN. 2025 Jul 24. Theranostics. 2023 May 8;13(9):2879-2895. Theranostics. 2025 May 25;15(13):6329-6346. Vaccines. 2023 May 25;11(6):1026. Vet Microbiol. 2025 Apr 23:305:110529. Virulence. 2025 Oct 28:2580150. Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. Immunobiology. 2024 Nov;229(6):152854. Int Immunopharmacol. 2024 Jan 5:126:111212. J Cell Sci. 2025 Nov 17:jcs.264186. OncoImmunology. 2023 Oct 12;12(1):2268257.
Smiles	O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SQ23377
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Category	Reference compound / Active compounds; Natural Products
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Product Description	Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].
Manufacturer - Research Area	Cancer; Infection
Manufacturer - Pathway	Anti-infection; Apoptosis; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; TGF-beta/Smad
Clinical information	No Development Reported
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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