Darunavir

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Darunavir is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. Darunavir is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. The Darunavir ethanolate (Prod. No. AG-CR1-3724) formulation has some stability advantages compared to the free base Darunavir. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain-like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.

This product is for research use only.