LAG3 Detection Set

ArtNr	PRS-SD8700-1Set
Hersteller	ProSci
Menge	1 Set
Kategorie	Other Assays & Kits Detection Kits
Typ	Detection Sets
Format	Liquid
Applikationen	FC, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Isotype	sdAb
Konjugat/Tag	Unconjugated
Dry ice	Yes
Citations	Huard B, Tournier M, Hercend T, et al. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol 1994; 24:3216–21. Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24:619–22. Workman CJ, Wang Y, El Kasmi KC, et al. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009; 182:1885–91. Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003; 33:970–9.
ECLASS 10.1	32161090
ECLASS 11.0	32161090
UNSPSC	41116126
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Storage Conditions	LAG3 antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Background	The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.
Set Contents	20 μg: LAG-3 Antibody [2A11], Cat. No. SD8837 LAG-3 Antibody [1A6], Cat. No. SD8839 LAG-3 Antibody [2B11], Cat. No. SD8841 LAG-3 Antibody [1C6], Cat. No. SD8842 LAG-3 Antibody [1A8], Cat. No. SD8843 100 μg: cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
Purification	LAG3 Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
Concentration	Antibody 1 mg/mL
Buffer	LAG3 Antibodies are supplied in PBS.
Immunogen	LAG3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
Clonality	Monoclonal
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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