TIGIT Detection Set

ArtNr	PRS-SD8800-1Set
Hersteller	ProSci
Menge	1 Set
Kategorie	Other Assays & Kits Detection Kits
Typ	Detection Sets
Format	Liquid
Applikationen	FC, IF, ICC, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Isotype	sdAb
Konjugat/Tag	Unconjugated
Dry ice	Yes
Citations	Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63. Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014; 26:923-37.
ECLASS 10.1	32161090
ECLASS 11.0	32161090
UNSPSC	41116126
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Storage Conditions	TIGIT antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Background	TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
Set Contents	20 μg: TIGIT Antibody [2B5], Cat. No. SD8824 TIGIT Antibody [2F7], Cat. No. SD8827 TIGIT Antibody [2C6], Cat. No. SD8828 TIGIT Antibody [2C7], Cat. No. SD8829 TIGIT Antibody [2D7], Cat. No. SD8830 100 μg: cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
Purification	TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
Concentration	Antibody 1 mg/mL
Buffer	TIGIT Antibodies are supplied in PBS.
Immunogen	TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
Clonality	Monoclonal
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 1 Set

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