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5 Lipoxygenase (ALOX5) Mouse Monoclonal Antibody [Clone ID: LBI2D7]

5 Lipoxygenase (ALOX5) Mouse Monoclonal Antibody [Clone ID: LBI2D7]

ArtNr	LBI-AMM17588V
Hersteller	Leading Biology
Menge	100 ul
Kategorie	Metabolism Cholesterol & Lipid Metabolism Antibodies Enzymes Leukotriene Metabolism
Typ	Antibody Monoclonal
Format	Liquid
Clon	LBI2D7
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Konjugat/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	5-LO, 5-LOX, 5LPG, LOG5
Lieferbar
Manufacturer - Category	mAbs-V
Manufacturer - Targets	ALOX5
Storage Conditions	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Field of Research	Arachidonic acid metabolism, Metabolic pathways
Overview	ALOX5 mouse monoclonal antibody, clone LBI2D7
Immunogen	Human recombinant protein fragment corresponding to amino acids 18-364 of human ALOX5(NP_000689) produced in E.coli.
Gene Name	arachidonate 5-lipoxygenase
Symbol	ALOX5
Function	Druggable Genome
Summary	This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8, 11, 14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7, 9-trans-11, 14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Manufacturer - Format	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Storage Buffer	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Dilution	WB 1:500
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway	Arachidonic acid metabolism, Metabolic pathways

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ul

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Lieferung vsl. bis 15.01.2026

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