MLH1 Mouse Monoclonal Antibody [Clone ID: LBI4H4]

MLH1

Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer

Human recombinant protein fragment corresponding to amino acids 339-558 of human MLH1 (NP_000240) produced in E.coli.

MLH1

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)