Anti-Hsc70 (Hsp73) Antibody (11119) - 100 µg

Antibody Products>Heat Shock and Stress Protein Antibodies|Primary Monoclonal Antibodies|Products

Next Day 2 - 8°C

Hsp70 genes, members of a multigene family, encode heat-inducible 70kDa heat- shock proteins that function as molecular chaperones. They have been identified in most organelles of eukaryotic cells as well as in bacteria. The N-terminus of Hsp70 binds ATP with high affinity and the C- terminus binds proteins and polypeptides. When cells are subjected to metabolic stress, Hsp70 is expressed. Hsp70 shares >90% sequence homology with Hsc70. Constitutively expressed Hsc70 forms a stable complex with the highly inducible Hsp70 in cells following heat shock. This interaction is regulated by ATP. Research on Hsc70 suggests that it plays a role in facilitating the recovery of centrosomal structure and function after heat shock.

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