Anti-Human E-Cadherin Antibody (34060) - 100μl

Antibody Products>Cancer Research Antibodies|Immunohistochemistry|Primary Monoclonal Antibodies|Products

Next Day 2 - 8°C

E-cadherin is a calcium-dependent intercellular adhesion molecule encoded by the CDH1 gene and present on epithelial cells. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer. When compared with invasive ductal carcinoma, E-cadherin expression is markedly reduced or absent in the great majority of invasive lobular carcinomas when studied by immunohistochemistry.

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.