Anti-PTEN (Phospho-Ser380) Antibody (43009) - 100μl

Immunohistochemistry|Antibody Products>Phospho-specific Antibodies|Primary Monoclonal Antibodies

Next Day 2 - 8°C

Phosphatase and tensin homolog (PTEN) was identified as a tumor suppressor that is mutated in many cancers. PTEN is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to the dual specificity protein tyrosine phosphatases. Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol- 3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.

1.0 mg/ml