Anti-Shank 3 Antibody (56463) - 100 µg

Antibody Products>Neuroscience and Signal Transduction Antibodies|Products

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Shank proteins are a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation. Shank 3 is also one of the latest genes to be associated with autism. A mutation in a single copy of Shank3 on chromosome 22q13 can result in communication disorders.

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