Anti-Epidermal Growth Factor-Like Protein 7 [2H2] - 100 µg

Antibody Products>Growth Factors/Cytokines/Receptor Antibodies|Primary Monoclonal Antibodies|Products

Next Day 2 - 8°C

EGF-L7 (Epidermal Growth Factor Like Protein 7) is a multi-domain protein containing two EGF like domains and one EMI domain. It is expressed almost exclusively in endothelial cells and functions to promote normal development of the vascular system. EGF-L7 is capable of antagonistic binding to Notch receptors resulting in the inhibition of Notch signaling in HUVEC and neural stem cells. In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF- L7 can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaB activation. Additionally, EGF-L7 is a chemoattractant for endothelial cells and binds to the extracellular matrix. The overexpression of EGF-L7 is observed in various cancers, and is generally correlated with increased metastasis and a poor prognosis.

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.