Alisporivir

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM/1mL
ArtNr HY-12559-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Alternative_Names
DEB-025, Debio-025, UNIL-025, [D-MeAla]3-[EtVal]4-CsA
CAS
254435-95-5
MWt
1216.63782
Formula
C63H113N11O12
Solubility
DMSO
Clinical_Information
Phase 3
Pathway
Anti-infection
Target
HCV
Biological Activity
Alisporivir (DEB-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
In Vitro: DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication[1]. Alisporivir (Debio-025) is an analogue of cyclosporine A and represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction[2]. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with alisporivir and ribavirin increases the anti-MERS-CoV activity in cell culture[3]. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines[4].
In Vivo: Combination treatment with alisporivir and ribavirin does not protect against SARS-CoV infection in a mouse model[3].
Menge: 10mM/1mL
Lieferbar: Out of stock
Listenpreis: 7.887,50 €
Preis: 7.887,50 €
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