Alisporivir

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 1mg
ArtNr HY-12559-1mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Alternative names
DEB-025.Debio-025.UNIL-025.[D-MeAla]3-[EtVal]4-CsA
CAS
254435-95-5
Biological activity
Alisporivir (DEB-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
In Vitro: DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication[1]. Alisporivir (Debio-025) is an analogue of cyclosporine A and represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction[2]. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with alisporivir and ribavirin increases the anti-MERS-CoV activity in cell culture[3]. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines[4].
In Vivo: Combination treatment with alisporivir and ribavirin does not protect against SARS-CoV infection in a mouse model[3].
MW
1216.63782
Formula
C63H113N11O12
Smiles
O[CH]([C](C(N[CH](C(N([CH](C(N([CH](C(N[CH](C(N([CH]1CC(C)C)C)=O)C(C)C)=O)C(C)C)CC)=O)C)C)=O)CC)=O)([H])N(C([CH](N(C([C](N(C([CH](N(C([C](NC([CH](NC1=O)C)=O)([H])C)=O)C)CC(C)C)=O)C)([H])CC(C)C)=O)C)C(C)C)=O)C)[CH](C)C/C=C/C
Solubility
DMSO
Clinical phase
No Development Reported
Pathway
Anti-infection
Target
HCV
Menge: 1mg
Lieferbar: In stock
Listenpreis: 987,50 €
Rabatt: -10,0%
Preis: 888,75 €
Sie sparen: 98,75 €
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