Thiamet G

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12588-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Thiamet-G
CAS No.
1009816-48-1
Purity
>98%
MW
2482993
Formula
C9H16N2O4S
Solubility
DMSO: >= 45 mg/mL
Biological Description
Thiamet G is a potent and selective inhibitor of O-GlcNAcase that demonstrates a Ki value of 21 nM.
IC50 value: 21 nM [1]
Target: O-GlcNAcase inhibitor
Thiamet G increases cellular O-GlcNAc-modified protein levels (EC50 = 30 nM) and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200 mg/kg/day). Thiamet G is the first highly potent O-GlcNAcase inhibitor known to be orally bioavailable and effectively cross the blood brain barrier.

Sicherheitsdatenblatt

HY-12588-10mM.pdf

Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 127,14 €
Rabatt: -10,0%
Preis: 114,43 €
Sie sparen: 12,71 €
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