ON123300

Hersteller MedChem Express
Kategorie Produkte / Inhibitors
Typ Inhibitors
Specific against other
Clon N/A
Menge 5mg
ArtNr HY-12624-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
ON-123300, ON 123300
CAS No.
1357470-29-1
Purity
>98%
MW
4295175
Formula
C24H27N7O
Solubility
10 mM in DMSO
Biological Description
ON123300 is a potent inhibitor of CDK4, with an IC50 of 3.8 nM, with little inhibitory activity against CDKs 1, 2, 5 and 8.
IC50 value: 3.8 nM [1]
Target: CDK4
in vitro: ON123300 is a novel kinase inhibitor, inhibits CDK4/6 and PI3K-delta and exhibits potent activity against mantle cell lymphomas (MCLs). [1] ON123300 is a low molecular weight multi-kinase inhibitor identified through a series of screens that supported further analyses for brain tumor chemotherapy. Biochemical assays indicated ON123300 was a strong inhibitor of Ark5 and CDK4 as well as growth factor receptor tyrosine kinases such as Beta-type platelet-derived growth factor receptor [PDGFRbeta]. ON123300 inhibited U87 glioma cell proliferation with an IC50 = 3.4 +/- 0.1 uM and reduced phosphorylation of Akt, yet it also unexpectedly induced Erk activation; both in a dose- and time-dependent manner that subsequently was attributed to relieving Akt-mediated C-Raf S259 inactivation and activating a p70S6K initiated PI3K negative feedback loop. [3]
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5mg
Lieferbar: In stock
Listenpreis: 190,36 €
Preis: 190,36 €
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