Mirk-IN-1

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12838-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
Dyrk1B/A-IN-1
CAS No.
1386979-55-0
Purity
>98%
MW
4983182
Formula
C23H17Cl2N5O4
Solubility
10 mM in DMSO
Biological Description
Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68+/-48 nM and 22+/-8 nM respectively.
IC50 value: 68+/-48/22+/-8 nM (Dyrk1B/Dyrk1A) [1]
Target: Dyrk inhibitor
Mirk-IN-1 had an EC50 of 1.9 +/-0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by
88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2].
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 255,71 €
Preis: 255,71 €
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