RO5028442

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-12981-10mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS
920022-47-5
MWt
437.9617
Formula
C25H28ClN3O2
Solubility
10 mM in DMSO
Clinical_Information
Phase 1
Pathway
GPCR/G Protein
Target
Vasopressin Receptor
Biological Activity
RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
IC50 & Target: Ki: 1 nM (hV1a receptor), 39 nM (mV1a receptor)[1]
In Vitro: RO5028442 (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RO5028442 shows high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies[1].

Menge: 10mg
Lieferbar: In stock
Listenpreis: 928,57 €
Rabatt: -10,0%
Preis: 835,71 €
Sie sparen: 92,86 €
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