Cysteamine (Hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 10mM*1mL (in DMSO)
ArtNr HY-77591-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
beta-MEA Hydrochloride, beta-Mercaptoethylamine Hydrochloride, 2-Aminoethanethiol Hydrochloride, 2-Mercaptoethylamine Hydrochloride, Decarboxycysteine Hydrochloride, MEA Hydrochloride, Thioethanolamine Hydrochloride
CAS No.
156-57-0
Purity
>98%
MW
1136096
Formula
C2H8ClNS
Solubility
10 mM in DMSO
Biological Description
Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.
Target: Others
Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cepsilon activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 uM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].
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Sicherheitsdatenblatt

HY-77591-10mM.pdf

Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 114,29 €
Rabatt: -10,0%
Preis: 102,86 €
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