MMAD (hydrochloride)

Hersteller MedChem Express
Kategorie Produkte / Inhibitors
Typ Inhibitors
Specific against other
Menge 50mg
ArtNr HY-79105-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Demethyldolastatin 10 hydrochloride, Monomethylauristatin D hydrochloride, Monomethyl Dolastatin 10 hydrochloride
CAS No.
173441-26-4
Purity
>98%
MW
8075253
Formula
C41H67ClN6O6S
Solubility
10 mM in DMSO
Biological Description
Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
IC50 value:
Target: Tubulin; ADCs toxin
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
Menge: 50mg
Lieferbar: In stock
Listenpreis: 1.612,14 €
Preis: 1.612,14 €
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