Capecitabine

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5g
ArtNr HY-B0016-5g
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
154361-50-9
Purity
>98%
MW
3593501
Formula
C15H22FN3O6
Solubility
10 mM in DMSO
Biological Description
Capecitabine is an oral prodrug that is converted to its only active metabolite, fluorouracil (FU), by thymidine phosphorylase.



IC50 & Target: DNA/RNA Synthesis[1]
In Vitro: Capecitabine is an anti-cancer chemotherapy drug. It is classified as an antimetabolite. Capecitabine is converted into 5?-deoxy-5-fluorocytidine (5?DFCR), 5?-deoxy-5-fluorouridine (5?DFUR) and 5-fluorouracil (5-FU) by carboxylesterases (CES1 and 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP), in both liver and tumour. Capecitabine induces a significant cytotoxic effect in vitro only at high concentrations. Mean IC50 values vary from 860 uM in COLO205 cells to 6000 uM in HCT8 cells[2].
In Vivo: A pharmacokinetic/pharmacodynamic study is carried out in mice bearing HCT 116 xenografts receiving 0.52 and 2.1 mmol/kg/d of Capecitabine by oral gavage. Capecitabine administered at 0.52 mmol/kg/day induces partial control of HCT 116 xenografts tumour growth: growth rate =7.5+/-0.5 on day 21. Capecitabine 2.1 mmol/kg/day achieves complete control of tumor growth during the treatment period: growth rate =1+/-0.2 on day 21[2].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5g
Lieferbar: In stock
Listenpreis: 225,71 €
Rabatt: -10,0%
Preis: 203,14 €
Sie sparen: 22,57 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen