Fludarabine

Hersteller MedChem Express
Kategorie Produkte / Inhibitors / Research Area / Oncology / Heart & Blood Cancer
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-B0069-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
F-ara-A, NSC 118218
CAS No.
21679-14-1
Purity
>98%
MW
2852318
Formula
C10H12FN5O4
Solubility
10 mM in DMSO
Biological Description
Fludarabine(NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.
Target:
Fludarabine or fludarabine ph osphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas). It is a purine analog, which interferes with DNA synthesis. Fludarabine is highly effective in the treatment of chronic lymphocytic leukemia, producing higher response rates than alkylating agents such as chlorambucil alone.
Fludarabine is a purine analog, and can be given both orally and intravenously. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Being phosphorylated, fludarabine is ionized at physiologic pH and is effectually trapped in blood. This provides some level of specificity for blood cells, both cancerous and healthy. Fludarabine is associated with the development of severe autoimmune hemolytic anemia in a proportion of patients. Difficulties are often encountered when harvesting peripheral blood stem cells from patients previously treated with fludarabine.
Menge: 10mg
Lieferbar: In stock
Listenpreis: 120,71 €
Preis: 120,71 €
lieferbar

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