Ethionamide

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 1g
ArtNr HY-B0276-1g
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
2-ethylthioisonicotinamide
CAS No.
536-33-4
Purity
>98%
MW
1662434
Formula
C8H10N2S
Solubility
10 mM in DMSO
Biological Description
Ethionamide(2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.
Target: Antibacterial
Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. Ethionamide is a prodrug. It is activated by the enzyme EthA, a mono-oxygenase in Mycobacterium tuberculosis, and binds NAD+ to form an adduct which inhibits InhA in the same way as isoniazid. Expression of the ethA gene is controlled by EthR, a transcriptional repressor. It is understood that improving ethA expression will increase the efficacy of ethionamide and so EthR inhibitors are of great interest to co-drug developers. The action may be through disruption of mycolic acid [1, 2].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!

Sicherheitsdatenblatt

HY-B0276-1g.pdf

Menge: 1g
Lieferbar: In stock
Listenpreis: 143,21 €
Rabatt: -10,0%
Preis: 128,89 €
Sie sparen: 14,32 €
lieferbar

Angebot anfordern

Fragen zum Produkt?

Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de

 
Schließen