7,4'-Dihydroxyflavone

7, 4'-Dihydroxyflavone (7, 4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7, 4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7, 4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7, 4'-Dihydroxyflavone (7, 4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7, 4'-Dihydroxyflavone (7, 4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].

Room Temperature

254.24

Inflammation/Immunology; Endocrinology

CCR; NF-κB

Natural Products