Tie2 kinase inhibitor 1

948557-43-5

439.53

DMSO : 17.86 mg/mL (40.63 mM; Need ultrasonic)

Others

Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC₅₀ of 250 nM^[1]. Tie2 kinase inhibitor 1 has anti-cancer activity^[2]. IC50 & Target: IC50: 250 nM (Tie2)^[1] In Vitro: Tie2 kinase inhibitor 1 (compound 5) has an IC₅₀ of 50 uM for p38 and has moderate to excellent cellular activities (cell IC₅₀=232 nM)^[1].
Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)^[2].
In Vivo: Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks^[1].