L-APB

23052-81-5

183.10

H2O : 50 mg/mL (273.07 mM; Need ultrasonic)

GPCR/G Protein; Neuronal Signaling

L-APB is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 uM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively. IC50 & Target: EC50: 0.13 uM (mGlu₄), 0.29 uM (mGlu₈), 1.0 uM (mGlu₆), 249 uM (mGlu₇)^[1]. In Vivo: Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6+/-2.4 g. The mechanical threshold decreases significantly (2.3+/-0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 ug of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration^[2].