Ruthenium red

11103-72-3

1000

10 mM in DMSO

Membrane Transporter/Ion Channel, Neuronal Signaling

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker^[1][2]. IC50 & Target: I_Ca^[2] In Vitro: Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used^[2].
Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC₅₀ of 0.8 uM^[2].
Ruthenium red (10 uM) blocks the sarcoplasmic Ca release channels or the mitochondrial Ca uptake, and blocks 26.7 % of the sodium current, and slowed its inactivation time-course in guinea-pig isolated ventricular heart cells^[2].