Neoseptin 3

1622863-21-1

474.59

DMSO : >= 100 mg/mL (210.71 mM)

Immunology/Inflammation

Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 uM. IC50 & Target: EC50: 18.5 uM (mTLR4/MD-2) ^[1] In Vitro: Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 uM. Neoseptin-3 induces TNFalpha production by macrophages in a concentration-dependent manner. Neoseptin-3 induces phosphorylation of IkappaB kinases alpha (IKKalpha), IKKbeta, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IkappaBalpha, consistent with activation of MAPK and canonical NF-kappaB signaling. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also increase in response to Neoseptin-3^[1].