MCP110

521310-51-0

508.65

DMSO : 250 mg/mL (491.50 mM; Need ultrasonic)

MAPK/ERK Pathway; GPCR/G Protein

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors^[1]. In Vitro: MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 uM) ^[1].
MCP110 (1, 2, 5, 10, and 20 uM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells^[1].
MCP110 (20 uM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells^[1].