Deoxycytidine triphosphate (trisodium salt)

109909-44-6

533.10

H₂O : 250 mg/mL (ultrasonic)

Cell Cycle/DNA Damage; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
In Vitro: Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-beta-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2?-Deoxycytidine-5?-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C.

Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate.