GIP (1-30) amide,Human (acetate)

3591.99

10 mM in DMSO

GPCR/G Protein

GIP (1-30) amide, Human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide (Human) dose-dependently promotes insulin secretion over the range 10^-9-10^-6 M^[1]. In Vitro: The glucose-dependent action of Glucose-dependent insulinotropic polypeptide (GIP) on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. In a 50% aqueous trifluoroethanol solvent, GIP(1-30) amide has an alpha-helical structural region from F6 to A28. The structures calculated for GIP(1-30) amide remain within one family of conformations and the level of agreement between the structures demonstrated the ordered arrangement^[1].