(Z)-4EGI-1

901787-88-0

451.28

DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60C)

Cell Cycle/DNA Damage

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC₅₀ of 43.5 uM and a K_d value of 8.74 uM. (Z)-4EGI-1 has anticancer activity^[1][2]. IC50 & Target: IC50: 43.5 uM (eIF4E)^[2]
Kd: 8.74 uM (eIF4E)^[1] In Vitro: (Z)-4EGI-1 (15-30 uM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as beta-Actin and alpha-Tubulin are not affected^[1].
(Z)-4EGI-1 inhibits cancer cells proliferation with IC₅₀ values of 15.3 uM and 11.6 uM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively^[2].