AMPK activator 4

2493239-46-4

420.89

10 mM in DMSO

Epigenetics; PI3K/Akt/mTOR

AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect^[1]. In Vitro: AMPK activator 4 (compound B10) (0-20 uM; 12-24 hours) induces phosphorylation of AMPK and its downstream protein ACC^[1].
AMPK activator 4-mediated AMPK phosphorylation requires LKB1^[1].
AMPK activator 4 slight decreases the viability of HepG2 cells after 72 hours of treatment at 10-20 uM^[1]. In Vivo: AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks) shows anti-hyperglycemic effect^[1].