mTOR inhibitor-8

2489196-70-3

446.95

DMSO : 25 mg/mL (ultrasonic)

PI3K/Akt/mTOR; Autophagy

mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
In Vitro: mTOR inhibitor-8 (Compound 5e; 0.1-10?uM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner.

mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10?uM; 3-24?hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced.

mTOR inhibitor-8 (10?uM; 3-24?hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR

In Vivo: mTOR inhibitor-8 (25 and 50 uM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis.