(Rac)-Benpyrine

1333714-43-4

308.34

DMSO : 12.5 mg/mL (40.54 mM; Need ultrasonic)

Apoptosis

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-alpha inhibitor. (Rac)-Benpyrine has the potential for TNF-alpha mediated inflammatory and autoimmune disease research^[1]. In Vitro: (Rac)-Benpyrine (Compound 001; 5-10 uM; 24 hours) treatment inhibits the expression level of TNF-alpha downstream pathway protein NF-kappaB in the nucleus in RAW264.7 macrophages^[1]. In Vivo: (Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-gamma, IL-1beta and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction^[1].