ICAM-1-IN-1

251994-14-6

363.23

DMSO : >= 135 mg/mL (371.67 mM)

Cytoskeleton

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC₅₀ values of 7 and 5 nM, respectively. IC50 & Target: IC50: 7 nM (E-selectin), 5 nM (ICAM-1)^[1] In Vivo: ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed^[1].