JNJ 16259685

Blue Ice

325, 41

Supplied as a white solid.

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34nM; IC50 = 0.55nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA ornMDA receptors (IC50 >10uM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

Synonyms:
(3, 4-Dihydro-2H-pyrano[2, 3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

CAS Number:
409345-29-5

Molecular Formula:
C₂₀H₂₃NO₃

Molecular Weight:
325.41

Primary Target:
mGlu1

Primary Target IC50:
0.55nM

Primary Target Ki:
0.34nM

Solubility:
DMSO

Storage and Stability:
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.