AT13148

ArtNr	V0170-100mg
Hersteller	InvivoChem LLC
CAS-Nr.	1056901-62-2
Menge	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Lieferbar
Description	InvivoChem Cat #:V0170CAS #:1056901-62-2Purity >=98% Description: AT13148 is a novel, potent, orally bioavailable, ATP-competitive, multi-AGC kinase inhibitor with potential anticancer activity. It inhibits Akt1/2/3, p70S6K, PKA, and ROCKI/II with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM respectively. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGKsubstrate phosphorylation and induced apoptosis in a concentration andtime-dependent manner in cancer cells with clinically relevant geneticdefects in vitro and in vivo. In addition, AT13148 has been revealed to inhibit proliferation with GI50 values of 1.54uM, 1.59uM, 1.82uM, 2.65uM and 3.77uM in MES-SA, BT474, HCT-116, A549 and SK-OV-3 cell lines, respectively. Description: Description: AT13148 is a novel, potent, orally bioavailable, ATP-competitive, multi-AGC kinase inhibitor with potential anticancer activity. It inhibits Akt1/2/3, p70S6K, PKA, and ROCKI/II with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM respectively. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGKsubstrate phosphorylation and induced apoptosis in a concentration andtime-dependent manner in cancer cells with clinically relevant geneticdefects in vitro and in vivo. In addition, AT13148 has been revealed to inhibit proliferation with GI50 values of 1.54uM, 1.59uM, 1.82uM, 2.65uM and 3.77uM in MES-SA, BT474, HCT-116, A549 and SK-OV-3 cell lines, respectively. Akt1/2/3, p70S6K, PKA, and ROCKI/II References:Clin Cancer Res. 2012 Jul 15; 18(14):3912-23. References:References: Related CAS #: 1056901-67-7 (R-isomer); 857532-13-9 (racemic)
Molecular Weight (MW)	313.78
Formula	C17H16ClN3O
CAS No.	1056901-62-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 62 mg/mL (197.59 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Synonym: AT-13148; AT 13148; AT13148; AT13148 hydrochloride; AT13148 HCl InChi Key: IIRWNGPLJQXWFJ-KRWDZBQOSA-N InChi Code: InChI=1S/C17H16ClN3O/c18-16-7-5-15(6-8-16)17(22, 11-19)14-3-1-12(2-4-14)13-9-20-21-10-13/h1-10, 22H, 11, 19H2, (H, 20, 21)/t17-/m0/s1 SMILES Code: ClC1=CC=C([C](C2=CC=C(C3=CNN=C3)C=C2)(O)CN)C=C1
Chemical Name	(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

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Menge: 100 mg

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