SRT1720 HCL (CAY-10559)

Description: SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt of SRT1720, is a novel, potent and selective SIRT1 (Sirtuin 1) activator with potential anticancer activity and is a promising new therapeutic agent for treating type 2 diabetes. It activated SIRT1 with an EC50 of 0.16 uM in a cell-free assay, but > 230-fold less potentcy against SIRT2 and SIRT3.

References: Nature. 2007 Nov 29; 450(7170):712-6; Br J Haematol. 2011 Dec; 155(5):588-98.

Related CAS: 1001645-58-4 (HCl) ; 925434-55-5 (free base)

SRT1720; CAY-10559 HCl; CAY10559; CAY 10559; SRT-1720 HCl, SRT-1720 hydrochloride; SRT1720 HCl; SRT-1720; SRT 1720; SIRT-1933; SIRT 1933; SIRT1933 HCl; CAY-10559;

Chemical Name: N-(2-(3-(piperazin-1-ylmethyl)imidazo[2, 1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide dihydrochloride

SMILES Code: O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=NC6=CC=CC=C6N=C5.[H]Cl.[H]Cl