Ferrostatin-1 (Fer-1)

Description: Ferrostatin-1 (also named as Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. It is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50 of 60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferroptosis is a regulated, oxidative, nanapoptotic cell death, Ferrostatin-1 has been founded as a potent inhibitor of it. Ferrostatin-1 can attenuate oxidative, iron-dependent cancer cell death through blocking cystine import and glutathione production. It had been reported to prevent Huntington's disease cellular models to death by inhibiting lipid peroxidation.

References: Cell. 2012 May 25; 149(5):1060-72.