(-)-Huperzine A (HupA)

Description: (-)-Huperzine A (Hup A; Selagine; (-)-Selagine) is a naturally occurring, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with neuroprotective activity. It inhibits AChE with Ki of 7 nM, and exhibits 200-fold more selectivity for G4 AChE over G1 AChE. Chemically, (-)-Huperzine A is an active Lycopodium alkaloid isolated from traditional Chinese herb. It also acts as an NMDA receptor antagonist. (-)-Huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration-particularly Alzheimer's disease. Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function.

References: Eur J Pharmacol. 2002 Nov 29; 455(2-3):101-7; Trends Pharmacol Sci. 2006 Dec; 27(12):619-25.