cyclizine-2hcl

Description: Cyclizine 2HCl (Marezine; Ciclizina; Nautazine; Valoid; Neo-devomit), the dihydrochloride salt of cyclizine, is a potent and 1st generation histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties. It has been used as a medication to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. The mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated. Cyclizine increases lower oesophageal sphincter tone and reduces the sensitivity of the labyrinthine apparatus. It may inhibit the part of the midbrain known collectively as the emetic centre.

References: Anaesthesia. 2013 Dec; 68(12):1284; J Pain Symptom Manage. 2013 May; 45(5):e5-7.