Mitoxantrone HCl (mitozantrone)

Description: Mitoxantrone HCl (formerly NSC-301739; NSC301739; DHAQ; CL-232325; Mitroxone; Neotalem; Onkotrone; Pralifan; Novantrone), the hydrochloride salt of Mitoxantrone which is an anthracenedione anticancer agent, is a potent type II topoisomerase inhibitor with potential antitumor activity. It inhibits TOPO II with IC50s of 2.0 uM, 0.42 mM in HepG2 and MCF-7/wt cells, respectively. It is used as an anti-neoplastic drug for leukemia and other types of cancer, and a proven drug for multiple sclerosis. Mitoxantrone suppressed the leukemia via inhibiting DNA synthesis and cell cycle progression. It had effect on different immune cells (e.g. T cell, B cell and macrophage etc.). It interfered with TOPO-II-mediated DNA cleavage and led to multiple DSB (DNA strand breaks), chromatin structure changes etc.

References: Curr Opin Rheumatol. 1999 May; 11(3):226-32; Neurology. 2004 Dec 28; 63(12 Suppl 6):S15-8.

Related CAS#:65271-80-9 (free base); 70476-82-3 (HCl salt)

NSC-301739; CL-232325; NSC301739; CL 232325; NSC 301739; DHAQ; CL232325; Mitozantrone; Mitoxantrone HCl; Mitoxantrone dihydrchloride; US brand name: Novantrone. NSC 301739; DHAQ; CL232325; Foreign brand names: Mitroxone; Neotalem; Onkotrone; Pralifan;

Chemical Name: 1, 4-dihydroxy-5, 8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9, 10-dione dihydrochloride

SMILES Code: O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl