InvivoChem Cat #:V14699CAS #:256414-75-2Purity >=98%Description: SEW2871 is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist). SEW2871 improves cognitive function in Alzheimer's disease model rats. SEW2871 prolongs heterotopic heart allograft survival in mice. SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. SEW2871 prolongs heterotopic heart allograft survival in mice.
References: Zou L, Ke L, Wu C, Tong Z, Li W, Li N, Li J. SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice. Biol Pharm Bull. 2015; 38(7):1012-9. doi: 10.1248/bpb.b15-00043. Epub 2015 May 2. PubMed PMID: 25948069.