Cinacalcet HCl (AMG-073)

Description: Cinacalcet HCl (also known as AMG-073; KRN1493; KRN-1493; Regpara; trade names Sensipar, Mimpara), the hydrochloride salt of Cinacalcet, is a calcimimetic that mimics the action of calcium on tissues by allosteric activation of the calcium-sensing receptor expressed in various human organ tissues. It is an approved a medication for the treatment of hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism. Cinacalcet is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR. In the presence of calcium ions, it can inhibit parathyroid hormone secretion by activating CaSR in parathyroid glands. Cinacalcet has been used clinically to treat secondary hyperparathyroidism due to end-stage renal disease or hypercalcemia in patients with parathyroid carcinoma.

References: Kidney Int Suppl. 2003 Jun; (85):S91-6; Clin Ther. 2005 Nov; 27(11):1725-51.

Related CAS#: 226256-56-0 (free base); 364782-34-3 (HCl)

AMG073 HCl; Cinacalcet Hydrochloride; Sensipar; AMG-073 HCl; AMG 073 HCl; KRN1493; KRN-1493; Cinacalcet HCl; Mimpara; Regpara; cinacalcet; cinacalcet hydrochloride; Hydrochloride, Cinacalcet; KRN 1493;

Chemical Name: N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; hydrochloride

SMILES Code: C[CH](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl